Sieber S M, Mead J A, Adamson R H
Cancer Treat Rep. 1976 Aug;60(8):1127-39.
Some pharmacologic properties of nine antitumor agents from higher plants are described. The agents are vincristine, vinblastine the epiodophyllotoxin derivatives VM-26 and VP-16-213, maytansine, bruceantin, thalicarpine, camptothecin, and lapachol. When sufficient information is available, the agents are discussed with regard to their antitumor activity, mechanism of action, pharmacologic disposition, structure-activity relationships, and toxicity.
本文描述了九种来自高等植物的抗肿瘤药物的一些药理学特性。这些药物包括长春新碱、长春碱、表鬼臼毒素衍生物VM - 26和VP - 16 - 213、美登素、鸦胆子素、紫堇达明碱、喜树碱和拉帕醇。当有足够的信息时，将对这些药物的抗肿瘤活性、作用机制、药理分布、构效关系和毒性进行讨论。
