克仑特罗对老年大鼠实验性甲状腺功能亢进后肌肉量及胴体蛋白质含量恢复的影响。

Effect of clenbuterol on recovery of muscle mass and carcass protein content following experimental hyperthyroidism in old rats.

作者信息

Carter W J, Lynch M E

机构信息

Veterans Administration Medical Center, Little Rock, AR 72205.

出版信息

Comp Biochem Physiol Comp Physiol. 1994 Jun-Jul;108(2-3):387-94. doi: 10.1016/0300-9629(94)90110-4.

DOI:10.1016/0300-9629(94)90110-4

PMID:7914859

Abstract

The beta 2-adrenoceptor agonist, clenbuterol, has hastened the recovery of skeletal muscle and carcass weights and carcass protein stores lost during experimental hyperthyroidism in 24-month-old rats. Daily injection of 6.5 micrograms T3 per 100 g body weight for 2 weeks and 4.0 micrograms for the third week caused a 17-22% reduction in total body, carcass and combined hindlimb muscle weights, and a 16-21% reduction in carcass protein stores. Feeding diet containing 10 mg clenbuterol per kg during a 3-week recovery period caused complete restoration of these parameters to euthyroid control levels while the feeding control diet did not.

摘要

β2-肾上腺素能受体激动剂克伦特罗，已加速了24月龄大鼠实验性甲状腺功能亢进期间丢失的骨骼肌、胴体重量及胴体蛋白质储备的恢复。每日按每100克体重注射6.5微克三碘甲状腺原氨酸，持续2周，第三周注射4.0微克，导致全身、胴体及后肢肌肉总重量减少17%-22%，胴体蛋白质储备减少16%-21%。在为期3周的恢复期内，喂食含每千克10毫克克伦特罗的饲料，可使这些参数完全恢复到甲状腺功能正常的对照水平，而喂食对照饲料则不能。