Carter W J, Lynch M E
Veterans Administration Medical Center, Little Rock, AR 72205.
Comp Biochem Physiol Comp Physiol. 1994 Jun-Jul;108(2-3):387-94. doi: 10.1016/0300-9629(94)90110-4.
The beta 2-adrenoceptor agonist, clenbuterol, has hastened the recovery of skeletal muscle and carcass weights and carcass protein stores lost during experimental hyperthyroidism in 24-month-old rats. Daily injection of 6.5 micrograms T3 per 100 g body weight for 2 weeks and 4.0 micrograms for the third week caused a 17-22% reduction in total body, carcass and combined hindlimb muscle weights, and a 16-21% reduction in carcass protein stores. Feeding diet containing 10 mg clenbuterol per kg during a 3-week recovery period caused complete restoration of these parameters to euthyroid control levels while the feeding control diet did not.
β2-肾上腺素能受体激动剂克伦特罗，已加速了24月龄大鼠实验性甲状腺功能亢进期间丢失的骨骼肌、胴体重量及胴体蛋白质储备的恢复。每日按每100克体重注射6.5微克三碘甲状腺原氨酸，持续2周，第三周注射4.0微克，导致全身、胴体及后肢肌肉总重量减少17%-22%，胴体蛋白质储备减少16%-21%。在为期3周的恢复期内，喂食含每千克10毫克克伦特罗的饲料，可使这些参数完全恢复到甲状腺功能正常的对照水平，而喂食对照饲料则不能。
