Carter W J, Lynch M E
Veterans Administration Medical Center, Little Rock, Arkansas.
J Gerontol. 1994 Jul;49(4):B162-8. doi: 10.1093/geronj/49.4.b162.
There is a need for new therapeutic agents designed to prevent or restore skeletal muscle loss in frail, elderly subjects resulting from injury or disease and associated catabolic stresses such as malnutrition. Since the beta 2-adrenergic agonist clenbuterol increases skeletal muscle mass in rats, the effect of this agent on recovery of muscle mass and carcass protein content following protein malnutrition was studied in young and old rats. The 3-week period of severe dietary protein restriction reduced body weight 21%, hind-limb muscle weight 24 and 15%, and carcass protein content 31 and 19%, respectively, in 3- and 24-month-old rats. During the 3-week recovery period induced by feeding a complete diet, 10 mg clenbuterol per kg diet increased hind-limb muscle weight 34 and 30% and carcass protein content 27 and 25%, respectively, in 3- and 24-month-old rats. Restoration was complete in animals of both ages fed clenbuterol and incomplete in animals fed the control diet. These observations suggest that clenbuterol or similar beta 2-adrenergic agonists may be useful in hastening the recovery of muscle mass and body protein stores lost because of malnutrition in frail, elderly humans.
需要设计新的治疗药物，以预防或恢复体弱的老年受试者因损伤或疾病以及诸如营养不良等相关分解代谢应激而导致的骨骼肌损失。由于β2 -肾上腺素能激动剂克伦特罗可增加大鼠的骨骼肌质量，因此在年轻和老年大鼠中研究了该药物对蛋白质营养不良后肌肉质量恢复和胴体蛋白质含量的影响。在3周的严重饮食蛋白质限制期间，3月龄和24月龄大鼠的体重分别降低了21%，后肢肌肉重量分别降低了24%和15%，胴体蛋白质含量分别降低了31%和19%。在通过喂食完整饮食诱导的3周恢复期内，每千克饮食中添加10毫克克伦特罗，3月龄和24月龄大鼠的后肢肌肉重量分别增加了34%和30%，胴体蛋白质含量分别增加了27%和25%。喂食克伦特罗的两个年龄组动物的恢复均已完成，而喂食对照饮食的动物恢复不完全。这些观察结果表明，克伦特罗或类似的β2 -肾上腺素能激动剂可能有助于加速体弱老年人类因营养不良而损失的肌肉质量和身体蛋白质储备的恢复。
