Tosaka Y, Ishimoto K, Sawaguchi S, Sekiya M
Department of Ophthalmology, Niigata University School of Medicine, Japan.
Nippon Ganka Gakkai Zasshi. 1994 Jul;98(7):704-9.
Using a polyclonal antibody to the c-erbB-2 oncogene product (ErbB-2 protein), an immunohistochemical study on the expression of ErbB-2 protein in lacrimal gland tumors was performed. The expression of ErbB-2 protein was observed in 4 (33.3%) of 12 cases of pleomorphic adenoma, but was not in two cases of adenoid cystic carcinoma and one case of normal lacrimal gland. The immunohistochemical reaction was localized in the cell membrane and cytoplasm, and was more intense in the former. There were strongly stained cells in the epithelium of ductal cell lineage and in the solid area, and some of the cells in the myxoid/chondroid areas were weakly stained. The relation ErbB-2 protein with the malignant lacrimal gland tumors in general is not clear, but pleomorphic adenomas of lacrimal gland could have some relation with this protein.
利用针对c-erbB-2癌基因产物（ErbB-2蛋白）的多克隆抗体，对泪腺肿瘤中ErbB-2蛋白的表达进行了免疫组织化学研究。在12例多形性腺瘤中有4例（33.3%）观察到ErbB-2蛋白表达，而2例腺样囊性癌和1例正常泪腺中未观察到该蛋白表达。免疫组织化学反应定位于细胞膜和细胞质，且在细胞膜上更强烈。导管细胞谱系的上皮和实性区域有强染色细胞，黏液样/软骨样区域的一些细胞弱染色。一般来说，ErbB-2蛋白与恶性泪腺肿瘤的关系尚不清楚，但泪腺多形性腺瘤可能与该蛋白有一定关系。
