Gniadecka M, Gniadecki R, Serup J, Søndergaard J
Department of Dermatology, Bispebjerg Hospital, University of Copenhagen, Denmark.
Acta Derm Venereol. 1994 May;74(3):191-3. doi: 10.2340/0001555574191193.
Normal microcirculation of the lower extremity is characterized by the venoarteriolar vasoconstriction reflex and the disappearance of vasomotion in the dependent position. Patients with sickle cell disease are prone to develop ischemic leg ulcers at an early age. Dysfunction of the microcirculation might promote the development of leg ulcers in patients with sickle cell disease. Using laser Doppler equipment we have studied the changes of blood flux in the skin overlying the medial malleolus after leg lowering. Contrary to the normal physiological situation seen in our control persons, the venoarteriolar reflex was abolished and vasomotion preserved in the dependent position of the leg in both patients. We conclude that this may represent an adaptation to the dependent position in sickle cell disease.
下肢正常微循环的特征是静脉小动脉血管收缩反射以及在下垂部位血管运动消失。镰状细胞病患者在早年容易发生缺血性腿部溃疡。微循环功能障碍可能会促进镰状细胞病患者腿部溃疡的发展。我们使用激光多普勒设备研究了腿部下垂后内踝上方皮肤的血流变化。与我们对照组观察到的正常生理情况相反，两名患者腿部下垂部位的静脉小动脉反射均消失，而血管运动得以保留。我们得出结论，这可能代表了镰状细胞病对下垂部位的一种适应性变化。
