Gniadecka M, Gniadecki R, Serup J, Søndergaard J
Department of Dermatology, Bispebjerg Hospital, Copenhagen, Denmark.
Acta Derm Venereol. 1994 May;74(3):194-6. doi: 10.2340/0001555574194196.
The venoarteriolar vasoconstriction reflex plays a major role in the prevention of leg oedema in the upright position in man. We studied the venoarteriolar vasoconstriction reflex with laser Doppler flowmetry in young (21 subjects, age 17-27) and very old (20 subjects, age 75-100) healthy volunteers. In the group of young volunteers, after lowering of the lower extremity 50 cm below the heart level, cutaneous blood flux decreased to 16.6% of the baseline, whereas in the group of old persons the venoarteriolar reflex was impaired and the flux decreased only to 29.2%. The difference between the two groups was statistically significant (p < 0.001). These results may explain the increased prevalence of postural oedema in old people.
静脉小动脉收缩反射在预防人体直立位时下肢水肿中起主要作用。我们用激光多普勒血流仪研究了年轻（21名受试者，年龄17 - 27岁）和非常年老（20名受试者，年龄75 - 100岁）健康志愿者的静脉小动脉收缩反射。在年轻志愿者组中，将下肢降低至心脏水平以下50厘米后，皮肤血流量降至基线的16.6%，而在老年组中静脉小动脉反射受损，血流量仅降至29.2%。两组之间的差异具有统计学意义（p < 0.001）。这些结果可能解释了老年人姿势性水肿患病率增加的原因。
