Lee S S, Lin H Y, Wang S R, Tsai C, Liu H N
Department of Internal Medicine, Veterans General Hospital, Taipei, Taiwan R.O.C.
J Formos Med Assoc. 1994 Jan;93(1):66-70.
The development of connective tissue diseases in patients who have had silicone gel breast implants has not been previously described in Taiwan. Herein, we report a 44-year-old female patient who underwent a silicone gel breast implant approximately 10 years prior to the onset of scleroderma. She developed generalized sclerosis, severe defective esophageal clearance, and severe reduction of gas exchange with DLco 37% of predicted value. Immunologic tests revealed that the antinuclear antibody titer was 1:2,560 with speckled pattern and positive anti-Scl-70 antibody. In spite of prednisolone and D-penicillamine treatment, her condition deteriorated. However, following the removal of the prosthesis, short-term subjective and objective improvements in both skin lesions and pulmonary function were noted. It is important that plastic surgeons, rheumatologists, and dermatologists, as well as primary care physicians, be aware of the possible association of sclerosis with silicone gel breast implants.
台湾此前未曾描述过接受硅胶乳房植入的患者发生结缔组织疾病的情况。在此，我们报告一名44岁女性患者，她在硬皮病发病前约10年接受了硅胶乳房植入。她出现了全身硬化、严重的食管清除功能缺陷以及气体交换严重降低，一氧化碳弥散量（DLco）为预测值的37%。免疫检查显示抗核抗体滴度为1:2560，呈斑点型，抗Scl - 70抗体阳性。尽管接受了泼尼松龙和青霉胺治疗，她的病情仍恶化。然而，在移除假体后，皮肤病变和肺功能在短期内出现了主观和客观的改善。整形外科医生、风湿病学家、皮肤科医生以及初级保健医生应意识到硬化症与硅胶乳房植入可能存在关联，这一点很重要。
