Clarke D J, Payne A P
Department of Human Anatomy, University of Oxford, UK.
Eur J Neurosci. 1994 May 1;6(5):885-8. doi: 10.1111/j.1460-9568.1994.tb01000.x.
A new mutant rat strain with movement disorders has arisen spontaneously in a closed colony of Albino-Swiss rats at the Department of Anatomy, Glasgow University. The animals possess a progressive locomotor disorder which is first apparent at around post-natal day 10. We here report that tyrosine hydroxylase immunocytochemistry demonstrates that these mutants have profound depletions in dopaminergic systems in the substantia nigra and corresponding areas of neostriatum.
在格拉斯哥大学解剖学系的白化瑞士大鼠封闭群体中，自发出现了一种患有运动障碍的新突变大鼠品系。这些动物患有进行性运动障碍，在出生后第10天左右首次明显表现出来。我们在此报告，酪氨酸羟化酶免疫细胞化学显示，这些突变体在黑质和新纹状体相应区域的多巴胺能系统中存在严重缺失。
