Le Dividich J, Herpin P, Mourot J, Colin A P
INRA, Station de Recherches Porcines, Saint Gilles, France.
Comp Biochem Physiol Comp Physiol. 1994 Aug;108(4):663-71. doi: 10.1016/0300-9629(94)90353-0.
Fat accretion, body fatty acid (FA) composition and adipose tissue lipogenic enzyme activities were determined in 1-day-old piglets fed during the first day of life sow colostrum that was either normal (control) or low in fat and high in lactose, galactose or glucose as the sole source of carbohydrate. Malic enzyme activity did not change during the first postnatal day while increases (P < 0.01) were found for glucose-6-phosphate dehydrogenase and acetyl-CoA-carboxylase. However, fat accretion was closely dependent on the amount of ingested fat and FA composition of piglets indicates a shift toward that of colostrum, the extent of which was dependent on the amount of ingested fat. Plasma glucose and insulin levels were the highest (P < 0.01) in piglets fed the colostrum high in glucose and plasma free fatty acid (FFA) levels were the lowest (P < 0.01) in piglets fed the low-fat, high-carbohydrate colostra. Liver weight and glycogen concentration were higher (P < 0.01) in piglets fed the colostra low in fat and high in carbohydrate than in those on the control colostrum. It is suggested that synthesis of fatty acids from carbohydrate is negligible in the newborn pig even in the presence of high plasma insulin and low plasma FFA levels. The metabolic fate of carbohydrate is discussed.
对出生首日的仔猪进行了脂肪蓄积、机体脂肪酸（FA）组成及脂肪组织生脂酶活性的测定。这些仔猪在出生第一天喂以初乳，初乳分为正常（对照）初乳，以及脂肪含量低、乳糖、半乳糖或葡萄糖含量高作为唯一碳水化合物来源的初乳。产后第一天苹果酸酶活性未发生变化，而葡萄糖-6-磷酸脱氢酶和乙酰辅酶A羧化酶活性增加（P<0.01）。然而，脂肪蓄积紧密依赖于摄入的脂肪量，仔猪的FA组成表明其向初乳的FA组成转变，转变程度取决于摄入的脂肪量。喂食高糖初乳的仔猪血浆葡萄糖和胰岛素水平最高（P<0.01），而喂食低脂、高碳水化合物初乳的仔猪血浆游离脂肪酸（FFA）水平最低（P<0.01）。喂食低脂、高碳水化合物初乳的仔猪肝脏重量和糖原浓度高于喂食对照初乳的仔猪（P<0.01）。研究表明，即使存在高血浆胰岛素和低血浆FFA水平，新生仔猪由碳水化合物合成脂肪酸的量也可忽略不计。文中还讨论了碳水化合物的代谢去向。
