Prattichizzo F A
I Unità Operativa Medicina Generale, Ospedale Degli Infermi di San Miniato, PI.
G Ital Cardiol. 1994 May;24(5):533-8.
Studying a patient with Cushing's disease by 24-hour indirect blood pressure monitoring, we confirmed that the normal nocturnal fall in blood pressure was absent, although the usual decrease in heart rate persisted. Thereafter we found a hypervariability in blood pressure and heart rate, which was reversed by treatment with betablockers and/or cyproheptadine. The therapy restored also the normal nocturnal fall in blood pressure. The low-dose cyproheptadine therapy normalized urinary free cortisol levels and restored a 24-hour blood pressure profile better than the low-dose beta-blocker therapy.
通过对一名库欣病患者进行24小时间接血压监测，我们证实患者夜间血压正常下降消失，尽管心率仍有通常的下降。此后，我们发现患者血压和心率存在高变异性，使用β受体阻滞剂和/或赛庚啶治疗后这种情况得到逆转。该治疗还恢复了夜间血压的正常下降。低剂量赛庚啶治疗使尿游离皮质醇水平正常化，并且比低剂量β受体阻滞剂治疗能更好地恢复24小时血压曲线。
