Munakata M, Imai Y, Abe K, Sasaki S, Minami N, Sekino H, Yoshinaga K
Department of Medicine, Tohoku University School of Medicine, Japan.
J Hypertens Suppl. 1988 Dec;6(4):S44-6.
The circadian blood pressure rhythm was compared between patients with Cushing's syndrome and those with essential hypertension or primary aldosteronism. In patients with essential hypertension or primary aldosteronism, clear nocturnal falls in systolic and diastolic blood pressure and the heart rate were observed. In contrast, in patients with Cushing's syndrome there was no nocturnal fall in blood pressure, and even a rise in some cases. In all cases with Cushing's syndrome, there was a nocturnal fall in the heart rate. Exogenous glucocorticoid abolished a nocturnal fall of blood pressure in patients with chronic glomerulonephritis or systemic lupus erythematosus, but did not affect nocturnal falls in the heart rate. These results indicate that the normal circadian rhythm of blood pressure may be regulated, at least in part, by the hypothalamopituitary-adrenal system.
比较了库欣综合征患者与原发性高血压或原发性醛固酮增多症患者的昼夜血压节律。在原发性高血压或原发性醛固酮增多症患者中，观察到收缩压、舒张压和心率在夜间明显下降。相比之下，库欣综合征患者夜间血压没有下降，甚至在某些情况下还会升高。在所有库欣综合征病例中，心率在夜间下降。外源性糖皮质激素消除了慢性肾小球肾炎或系统性红斑狼疮患者夜间血压的下降，但不影响心率的夜间下降。这些结果表明，正常的昼夜血压节律可能至少部分受下丘脑 - 垂体 - 肾上腺系统调节。
