Antipsychotic drugs: is more worse? A meta-analysis of the published randomized control trials.
作者信息
Bollini P, Pampallona S, Orza M J, Adams M E, Chalmers T C
机构信息
Technology Assessment Group, Harvard School of Public Health, Boston, MA.
出版信息
Psychol Med. 1994 May;24(2):307-16. doi: 10.1017/s003329170002729x.
PMID:7916157
Abstract
Effectiveness and side-effects of high- versus low-dose neuroleptic treatment of chronic psychosis have been assessed through a meta-analysis of 22 published randomized control trials comparing different neuroleptic doses. No incremental clinical improvement was found at doses above 375 mg equivalent of chlorpromazine, while a significant increase in adverse reactions was observed.
摘要
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