Bollini P, Pampallona S, Orza M J, Adams M E, Chalmers T C
Technology Assessment Group, Harvard School of Public Health, Boston, MA.
Psychol Med. 1994 May;24(2):307-16. doi: 10.1017/s003329170002729x.
Effectiveness and side-effects of high- versus low-dose neuroleptic treatment of chronic psychosis have been assessed through a meta-analysis of 22 published randomized control trials comparing different neuroleptic doses. No incremental clinical improvement was found at doses above 375 mg equivalent of chlorpromazine, while a significant increase in adverse reactions was observed.
