问题多于答案：抗组胺药与癌症的关联 - Suppr

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More questions than answers: antihistamines' link to cancer.问题多于答案：抗组胺药与癌症的关联

CMAJ. 1994 Sep 15;151(6):797-801.

Cardiac actions of antihistamines.抗组胺药的心脏作用。

Annu Rev Pharmacol Toxicol. 1996;36:233-52. doi: 10.1146/annurev.pa.36.040196.001313.

Enhanced cancer growth in mice administered daily human-equivalent doses of some H1-antihistamines: predictive in vitro correlates.在每日给予相当于人类剂量的某些H1抗组胺药的小鼠中，癌症生长增强：体外预测相关性。

J Natl Cancer Inst. 1994 May 18;86(10):770-5. doi: 10.1093/jnci/86.10.770.

Fixed drug eruption due to three antihistamines of a same chemical family: Cetirizine, levocetirizine, and hydroxyzine.同一化学家族的三种抗组胺药（西替利嗪、左西替利嗪和羟嗪）引起的固定性药疹。

Dermatol Ther. 2017 Mar;30(2). doi: 10.1111/dth.12412. Epub 2016 Sep 9.

Non sedating antihistamines.非镇静性抗组胺药。

Aust Fam Physician. 1993 Sep;22(9):1649-53.

Re: Enhanced cancer growth in mice administered daily human-equivalent doses of some H1-antihistamines: predictive in vitro correlates.回复：给予小鼠每日人体等效剂量的某些H1抗组胺药后癌症生长增强：体外预测相关性

J Natl Cancer Inst. 1995 Nov 1;87(21):1638-9. doi: 10.1093/jnci/87.21.1638.

Risks of non-sedating antihistamines.非镇静性抗组胺药的风险。

Lancet. 1997 May 3;349(9061):1322. doi: 10.1016/S0140-6736(97)26018-6.

Of injuries and antihistamines and dosing.关于损伤、抗组胺药及剂量。

Ann Allergy Asthma Immunol. 2002 Sep;89(3):221-3. doi: 10.1016/S1081-1206(10)61946-1.

Comparative analysis of the cardiotoxicity proclivities of second generation antihistamines in an experimental model predictive of adverse clinical ECG effects.在一个可预测不良临床心电图效应的实验模型中，对第二代抗组胺药的心脏毒性倾向进行比较分析。

Arzneimittelforschung. 1996 Feb;46(2):153-8.

Pharmacokinetic overview of oral second-generation H1 antihistamines.口服第二代H1抗组胺药的药代动力学概述。

Int J Clin Pharmacol Ther. 1998 May;36(5):292-300.

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Results of a clinical trial in humans with refractory cancer of the intracellular histamine antagonist, N,N-diethyl-2-[4-(phenylmethyl)phenoxy]ethanamine-HCl, in combination with various single antineoplastic agents.

J Clin Oncol. 1994 Jun;12(6):1281-90. doi: 10.1200/JCO.1994.12.6.1281.

Between science and technology: the case of antihistamines and cancer.科学与技术之间：抗组胺药与癌症的案例

J Natl Cancer Inst. 1994 May 18;86(10):740-1. doi: 10.1093/jnci/86.10.740.

Endometrial cancer in tamoxifen-treated breast cancer patients: findings from the National Surgical Adjuvant Breast and Bowel Project (NSABP) B-14.他莫昔芬治疗的乳腺癌患者中的子宫内膜癌：来自国家外科辅助乳腺和肠道项目（NSABP）B-14的研究结果。

J Natl Cancer Inst. 1994 Apr 6;86(7):527-37. doi: 10.1093/jnci/86.7.527.

J Natl Cancer Inst. 1994 May 18;86(10):770-5. doi: 10.1093/jnci/86.10.770.

Initial screening for carcinogenicity of commonly used drugs.常用药物致癌性的初步筛查。

J Natl Cancer Inst. 1980 Oct;65(4):723-33. doi: 10.1093/jnci/65.4.723.

Screening for possible drug carcinogenicity: second report of findings.

J Natl Cancer Inst. 1983 Dec;71(6):1165-75.

Screening prescription drugs for possible carcinogenicity: eleven to fifteen years of follow-up.筛查处方药的潜在致癌性：长达11至15年的随访

Cancer Res. 1989 Oct 15;49(20):5736-47.

Stimulation of malignant growth in rodents by antidepressant drugs at clinically relevant doses.临床相关剂量的抗抑郁药物对啮齿动物恶性肿瘤生长的刺激作用。

Cancer Res. 1992 Jul 1;52(13):3796-800.

H3 receptor antagonist, thioperamide, inhibits adrenal steroidogenesis and histamine binding to adrenocortical microsomes and binds to cytochrome P450.H3受体拮抗剂硫代丙酰胺可抑制肾上腺类固醇生成，抑制组胺与肾上腺皮质微粒体的结合，并与细胞色素P450结合。

Br J Pharmacol. 1992 Sep;107(1):161-4. doi: 10.1111/j.1476-5381.1992.tb14480.x.

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More questions than answers: antihistamines' link to cancer.

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