Ramella G, Costagli V, Sogni A, Casella G, Capra C
Servizio di Anestesia e Rianimazione, Ospedale di Abbiategrasso, Milano.
Minerva Anestesiol. 1994 Apr;60(4):181-4.
Forty patients over 65 undergoing subarachnoid anesthesia with bupivacaine 0.50% (5 mg) and fentanyl (0.1 mg) were subdivided into two equal groups: one was premedicated with atropine and chlordesmethyldiazepam (0.03 mg/kg-1) and the other with atropine and diazepam (0.015 mg/Kg-1). A statistically significant difference was found in the group treated with diazepam which required an increase for anesthetic drugs during surgery. The authors suggest a probable synergic or an enhanced effect between intramuscular chlordesmethyldiazepam and opiates in spinal anesthesia.
40名65岁以上接受0.50%布比卡因（5毫克）和芬太尼（0.1毫克）蛛网膜下腔麻醉的患者被分为两组，每组人数相等：一组术前用阿托品和氯氮卓（0.03毫克/千克）进行预处理，另一组用阿托品和地西泮（0.015毫克/千克）进行预处理。结果发现，接受地西泮治疗的组在手术期间需要增加麻醉药物用量，存在统计学上的显著差异。作者认为，肌肉注射氯氮卓和阿片类药物在脊髓麻醉中可能存在协同或增强作用。
