Lin F K, Lin C H, Chou C C, Chen K, Lu H S, Bacheller W, Herrera C, Jones T, Chao J, Chao L
Amgen Inc., Amgen Center, Thousand Oaks, CA 91320.
Biochim Biophys Acta. 1993 Jun 25;1173(3):325-8. doi: 10.1016/0167-4781(93)90131-v.
Cynomolgus monkey renal kallikrein cDNA and genomic human tissue kallikrein gene were cloned. The monkey gene encodes a 257 amino acid (aa) preprokallikrein and exhibits 95% and 92% homology to the human at nucleotide (nt) and aa level, respectively. The monkey gene encodes a 233-aa mature kallikrein versus a 238-aa in human. The human kallikrein gene and urinary kallikrein both contain a Lys-162 instead of the reported Glu-162. Human, monkey and rat renal/pancreatic kallikrein genes evolve with a N-glycosylation containing domain (aa 81-87) which is absent in porcine and is non-glycosylable in mice. Only human kallikrein evolves with an additional Thr-108 and with a N-glycosylation site at aa-141.
