狒狒受体糖蛋白GPIbβ链编码cDNA的特性分析
Characterization of a cDNA encoding the beta-chain of baboon receptor glycoprotein GPIb.
作者信息
Hayzer D J, Shoji M, Kim T M, Runge M S, Hanson S R
机构信息
Division of Cardiology, Emory University School of Medicine, Atlanta, GA 30322.
出版信息
Gene. 1993 May 30;127(2):271-2. doi: 10.1016/0378-1119(93)90733-j.
PMID:7916710
Abstract
A cDNA probe, encoding part of the baboon integrin polypeptide, GPIIb, was used to screen a cDNA library derived from baboon platelet polyadenylated mRNA. One cross-hybridizing clone was found to be 94% similar to a human cDNA encoding the beta-chain of the receptor for von Willebrand factor, a major component of the platelet-subendothelium attachment mechanism.
摘要
使用一个编码狒狒整合素多肽GPIIb部分序列的cDNA探针，筛选来自狒狒血小板多聚腺苷酸化mRNA的cDNA文库。发现一个交叉杂交克隆与编码血管性血友病因子受体β链的人类cDNA有94%的相似性，血管性血友病因子是血小板-内皮下附着机制的主要成分。
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