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Human and baboon integrin beta 5 subunit-encoding mRNAs have alternative polyadenylation sites.

作者信息

Shoji M, Hayzer D J, Kim T M, Runge M S, Hanson S R

机构信息

Division of Hematology-Oncology, Emory University School of Medicine, Atlanta, GA 30322.

出版信息

Gene. 1993 Nov 15;133(2):307-8. doi: 10.1016/0378-1119(93)90659-q.

DOI:10.1016/0378-1119(93)90659-q
PMID:8224922
Abstract

A cDNA probe, encoding part of the human integrin polypeptide, GPIIIa (beta 3), was used to screen a cDNA library derived from baboon smooth muscle polyadenylated mRNA. One cross-hybridizing clone, lacking the baboon equivalent of 478 bp of the human sequence, was found to be 98% similar to a human cDNA encoding the beta 5-chain of the receptor for vitronectin, a cell adhesion molecule. The baboon mRNA terminates at 3' position 212 nucleotides upstream from the polyadenylation site of the aligned human mRNA.

摘要

相似文献

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引用本文的文献

1
cDNA cloning reveals two mouse beta5 integrin transcripts distinct in cytoplasmic domains as a result of alternative splicing.互补DNA克隆揭示，由于可变剪接，小鼠β5整联蛋白有两种在胞质结构域不同的转录本。
Biochem J. 1998 Apr 15;331 ( Pt 2)(Pt 2):631-7. doi: 10.1042/bj3310631.