DeFranco A L
GW Hooper Foundation, University of California, San Francisco 94143-0552.
Curr Opin Immunol. 1994 Jun;6(3):364-71. doi: 10.1016/0952-7915(94)90114-7.
Antigen and cytokine receptors induce rapid tyrosine phosphorylation of receptor subunits, other membrane proteins, and signaling components. Each receptor induces phosphorylation of a number of proteins. Although there is often overlap between targets of different receptors, any given receptor only induces phosphorylation of a subset of possible targets. How this choice of targets is achieved for these receptors is not yet understood. The cellular events downstream of some signaling components are beginning to come into view. Recent progress in these areas is discussed.
抗原和细胞因子受体可诱导受体亚基、其他膜蛋白及信号转导成分发生快速酪氨酸磷酸化。每种受体都会诱导多种蛋白质发生磷酸化。尽管不同受体的作用靶点常常存在重叠，但任何一种特定受体仅能诱导一部分可能的靶点发生磷酸化。这些受体如何实现对靶点的这种选择尚不清楚。一些信号转导成分下游的细胞事件正逐渐明晰。本文将讨论这些领域的最新进展。
