Gray D
Department of Immunology, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK.
Curr Opin Immunol. 1994 Jun;6(3):425-30. doi: 10.1016/0952-7915(94)90122-8.
Immunological memory can be regulated during either its development or its maintenance phases. Controversy and confusion surround both methods of regulation, especially in the field of T-cell memory. Recent work has helped in improving our definition of 'a memory cell', but this has been complicated by another major point of contention: whether memory cells are maintained by antigens or other stimuli. Unequivocal advances have recently been made concerning the molecular events involved in memory B cell generation in germinal centers.
免疫记忆在其发育或维持阶段均可受到调控。围绕这两种调控方式存在争议和困惑，尤其是在T细胞记忆领域。近期的研究有助于改进我们对“记忆细胞”的定义，但这又因另一个主要争议点而变得复杂：记忆细胞是由抗原还是其他刺激维持。最近在生发中心记忆B细胞产生所涉及的分子事件方面取得了明确进展。
