Ahmed R, Gray D
Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA, USA.
Science. 1996 Apr 5;272(5258):54-60. doi: 10.1126/science.272.5258.54.
The immune system can remember, sometimes for a lifetime, the identity of a pathogen. Understanding how this is accomplished has fascinated immunologists and microbiologists for many years, but there is still considerable debate regarding the mechanisms by which long-term immunity is maintained. Some of the controversy stems from a failure to distinguish between effector and memory cells and to define their roles in conferring protection against disease. Here the current understanding of the cellular basis of immune memory is reviewed and the relative contributions made to protective immunity by memory and effector T and B cells are examined.
免疫系统能够记住病原体的特征，有时这种记忆会持续一生。多年来，了解这一过程是如何实现的一直吸引着免疫学家和微生物学家，但关于维持长期免疫的机制仍存在相当大的争议。部分争议源于未能区分效应细胞和记忆细胞，以及未能明确它们在提供疾病防护方面的作用。本文将综述目前对免疫记忆细胞基础的理解，并探讨记忆T细胞和B细胞以及效应T细胞和B细胞对保护性免疫的相对贡献。
