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[千叶县袖ケ浦市脑性麻痹、精神发育迟滞及唐氏综合征的发病率]

[Incidence rates of cerebral palsy, mental retardation and Down syndrome in Sodegaura City, Chiba Prefecture].

作者信息

Yamada K

机构信息

Department of Pediatrics, Metropolitan Medical Center for the Severely Handicapped, Tokyo.

出版信息

No To Hattatsu. 1994 Sep;26(5):411-7.

PMID:7917491
Abstract

For the purpose of early detection and early habilitation for developmentally handicapped children, we started medical screening in 1978 for pediatric neurological diseases among children in Sodegaura City, Chiba Prefecture with a total population of about 50,000. A statistical analysis were performed for the incidence of cerebral palsy (CP), mental retardation (MR, I.Q < 70) and Down syndrome (Down). The number of liveborn babies during 1978-1987 was 5,070. The number of patients with CP, MR and Down were 11, 44 and 5 respectively. The incidence rates of CP, MR and Down were 0.217%, 0.868% and 0.099% respectively, which were almost equal to those recent reports. The rate of perinatal brain damage with CP was 81.8%. The incidence rates of mild MR (MMR, I.Q 69-50) and severe MR (SMR, I.Q < 50) were 0.512% and 0.355% respectively. The SMR rate was almost equal to recent reports, and the MMR rate was different from some reports. The rates of prenatal brain damage, perinatal brain damage, postneonatal brain damage and unknown origin with MR were 20.5%, 22.7%, 4.5% and 34.1% respectively. The rate of perinatal disorders, which play some role in the etiology of MR, was 18.2%. Even now, the perinatal disorders play a major role of CP and MR. Therefore the progress of perinatal medicine is strongly desired.

摘要

为了对发育障碍儿童进行早期发现和早期康复训练,我们于1978年开始对千叶县袖浦市约5万总人口中的儿童进行儿科神经疾病的医学筛查。对脑瘫(CP)、智力迟钝(MR,智商<70)和唐氏综合征(唐氏)的发病率进行了统计分析。1978 - 1987年期间的活产婴儿数量为5070名。CP、MR和唐氏患者的数量分别为11名、44名和5名。CP、MR和唐氏的发病率分别为0.217%、0.868%和0.099%,这与最近的报告几乎相同。CP患儿围产期脑损伤的发生率为81.8%。轻度智力迟钝(MMR,智商69 - 50)和重度智力迟钝(SMR,智商<50)的发病率分别为0.512%和0.355%。SMR发病率与最近的报告几乎相同,而MMR发病率与一些报告不同。MR患儿产前脑损伤、围产期脑损伤、新生儿后期脑损伤和病因不明的发生率分别为20.5%、22.7%、4.5%和34.1%。在MR病因中起一定作用的围产期疾病发生率为18.2%。即使在现在,围产期疾病在CP和MR的病因中仍起主要作用。因此,迫切需要围产医学的进步。

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