唑吡坦对重度打鼾者睡眠结构、夜间通气、日间警觉性及表现的影响。
Effects of zolpidem on sleep architecture, night time ventilation, daytime vigilance and performance in heavy snorers.
作者信息
Quera-Salva M A, McCann C, Boudet J, Frisk M, Borderies P, Meyer P
机构信息
Unité de Sommeil, Hôpital Raymond Poincaré, Garches, France.
出版信息
Br J Clin Pharmacol. 1994 Jun;37(6):539-43. doi: 10.1111/j.1365-2125.1994.tb04301.x.
Abstract
- In a double-blind, crossover, placebo controlled trial, zolpidem 10 mg, a new imidazopyridine hypnotic drug, was administered in a single dose to 10 healthy non-obese heavy snorers. 2. Nocturnal polysomnography showed that zolpidem increased total sleep time, sleep efficiency and the percentage of stage 2. 3. Respiratory monitoring showed that zolpidem did not modify the percentage of total sleep time spent snoring. The percentages of total sleep time with a SaO2 < 4% of the baseline value and with a SaO2 < 90% and the mean SaO2 were also unchanged with zolpidem. The respiratory disturbance index was modestly increased by zolpidem although in all but one subject it remained < 5 with both treatments. 4. Zolpidem intake did not impair daytime vigilance and performance evaluated the day after.
摘要
- 在一项双盲、交叉、安慰剂对照试验中，对10名健康的非肥胖重度打鼾者单次服用10毫克新型咪唑吡啶催眠药唑吡坦。2. 夜间多导睡眠图显示，唑吡坦增加了总睡眠时间、睡眠效率和2期睡眠的百分比。3. 呼吸监测显示，唑吡坦并未改变打鼾所占用的总睡眠时间百分比。唑吡坦治疗后，血氧饱和度低于基线值4%、低于90%的总睡眠时间百分比以及平均血氧饱和度也均未改变。尽管除一名受试者外，所有受试者在两种治疗下的呼吸紊乱指数均保持<5，但唑吡坦仍使其略有增加。4. 服用唑吡坦并未损害次日评估的日间警觉性和表现。
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