B 细胞慢性淋巴细胞白血病中的 12 三体：应用直接荧光原位杂交（FISH）对 33 例患者的评估
Trisomy 12 in B-cell chronic lymphocytic leukaemia: an evaluation of 33 patients by direct fluorescence in situ hybridization (FISH).
作者信息
Bienz N, Cardy D L, Leyland M J, Hultén M A
机构信息
Department of Haematology, East Birmingham Hospital.
出版信息
Br J Haematol. 1993 Dec;85(4):819-22. doi: 10.1111/j.1365-2141.1993.tb03233.x.
Abstract
An adaptation of the standard fluorescence in situ hybridization (FISH) technique allowing rapid analysis (4 h) has been used to study the prevalence of trisomy 12 in 33 patients with B-CLL, of whom 54% have been shown to have this abnormality. The presence of trisomy 12 has been compared with clinical parameters, and there may be a relationship between the prevalence of trisomy 12 in B-CLL and duration of disease.
摘要
一种标准荧光原位杂交（FISH）技术的改良方法可实现快速分析（4小时），已被用于研究33例B细胞慢性淋巴细胞白血病（B-CLL）患者中12号三体的患病率，其中54%的患者被证实存在这种异常。已将12号三体的存在情况与临床参数进行了比较，并且B-CLL中12号三体的患病率与疾病持续时间之间可能存在关联。
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