Dyess D L, Tacchi E, Powell R Q, Ardell J L, Roberts W S, Ferrara J J
Department of Surgery, University of South Alabama Mobile.
J Invest Surg. 1994 May-Jun;7(3):235-42. doi: 10.3109/08941939409018288.
This study was designed to determine whether a pregnant sow could be maintained under conditions of prolonged general anesthesia in order to provide access to prematurely delivered piglets for purposes of acute experimentation. Fifteen time-dated pregnant (90% of gestation) sows were preanesthetized with intramuscular xylazine (Rompun Mobay Pharmaceutical, Shawnee, KS)/ketamine (Aveco Pharmaceutical, Fort Dodge, IA). After anesthesia was induced with intravenous sodium thiopental, the animals underwent tracheotomy and mechanical ventilation. The electrocardiogram was monitored externally; systemic arterial pressure was supervised by the insertion of a brachial artery cannula; and urine output was determined by inserting a cystostomy tube. A surgical plane of anesthesia was achieved by the "balanced" technique: an inhalant, isoflurane, supplemented by intravenous doses of sufentanil citrate, propofol (Stuart Pharmaceuticals, Wilmington, DE), and vecuronium. Sows were maintained under general anesthesia for an average of 12 h; piglets were delivered, one or two at a time, by a modified cesarean section technique. No sows or piglets were lost to anesthetic complications. It is concluded that, with appropriate precautions, pregnant sows can be anesthetized for a prolonged period of time, and provide viable premature neonates for acute experimentation.
本研究旨在确定妊娠母猪是否能在长时间全身麻醉的条件下维持，以便为急性实验获取早产仔猪。15头已确定妊娠时间（妊娠90%）的母猪先用肌肉注射赛拉嗪（Rompun，莫贝制药公司，堪萨斯州肖尼）/氯胺酮（阿韦科制药公司，爱荷华州道奇堡）进行预麻醉。静脉注射硫喷妥钠诱导麻醉后，对动物进行气管切开和机械通气。外部监测心电图；通过插入肱动脉插管监测体动脉压；通过插入膀胱造瘘管测定尿量。采用“平衡”技术达到手术麻醉平面：吸入异氟烷，并静脉注射枸橼酸舒芬太尼、丙泊酚（斯图尔特制药公司，特拉华州威尔明顿）和维库溴铵。母猪平均在全身麻醉下维持12小时；通过改良剖宫产技术每次分娩1或2头仔猪。没有母猪或仔猪因麻醉并发症死亡。得出的结论是，采取适当的预防措施后，妊娠母猪可长时间麻醉，并能为急性实验提供存活的早产新生儿。
