Sims C D, Butler P E, Casanova R, Randolph M A, Yaremchuk M J
Division of Plastic Surgery, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA.
J Invest Surg. 1997 Jan-Apr;10(1-2):53-7. doi: 10.3109/08941939709032126.
A protocol utilizing high preoperative doses of altrenogest (Regu-Mate) and a "balanced" general anesthesia regimen consisting of isoflurane at subanesthetic doses supplemented with intravenous doses of sodium thiopental was developed to prevent preterm labor, minimize intracranial fetal cerebral edema, and decrease postpartum mortality of fetal swine after undergoing complex in utero craniofacial procedures. A total of 20 fetal piglets at 75% gestation were exposed to prolonged (> 3 h) anesthesia conditions of which 7 piglets were randomly selected to undergo experimental craniofacial procedures consisting of periosteal stripping of frontal and parietal bone segments with/without extensive coronal suture fusion procedures. Neither sows nor piglets were lost to anesthetic complications during the initial laparotomy or subsequent cesarean delivery. None of the sows experienced uterine sepsis or underwent preterm labor. The overall survival rate for all piglets exposed to prolonged anesthesia conditions was 95% at 4 weeks and 45% at 11 weeks after surgery. The experimental group's survival was 85.7% at 4 weeks and 28.5% at 11 weeks after surgery.
制定了一项方案，使用高剂量术前烯丙孕素（Regu-Mate）以及由亚麻醉剂量异氟烷补充静脉注射硫喷妥钠组成的“平衡”全身麻醉方案，以预防早产、使胎儿猪颅内脑水肿最小化，并降低接受复杂子宫内颅面手术后胎儿猪的产后死亡率。总共20只妊娠75%的胎儿仔猪暴露于延长（>3小时）麻醉条件下，其中7只仔猪被随机选择接受实验性颅面手术，包括额骨和顶骨节段的骨膜剥离，伴或不伴广泛冠状缝融合手术。在初次剖腹术或随后的剖宫产过程中，母猪和仔猪均未因麻醉并发症死亡。没有母猪发生子宫败血症或早产。所有暴露于延长麻醉条件下的仔猪术后4周总体存活率为95%，术后11周为45%。实验组术后4周存活率为85.7%，术后11周为28.5%。
