Spence M A, Westlake J, Lange K, Gold D P
Hum Hered. 1976;26(5):327-36. doi: 10.1159/000152824.
Data on cleft lip with or without cleft palate are utilized to evaluate a new method for estimating recurrence risk under the polygenic threshold model. The influence of critical factors on the accuracy of the estimated risks are evaluated. The model is relatively sensitive to the estimate of heritability employed and relatively robust to the population prevalence estimate and to family size. The calculated risks for cleft lip with or without cleft palate are contrasted with the empiric figures from studies on Caucasians and Japanese populations.
唇裂伴或不伴腭裂的数据被用于评估多基因阈值模型下估计复发风险的一种新方法。评估了关键因素对估计风险准确性的影响。该模型对所采用的遗传度估计相对敏感，而对人群患病率估计和家庭规模相对稳健。计算出的唇裂伴或不伴腭裂的风险与白种人和日本人群研究中的经验数据进行了对比。
