来自兔肾的一个假定转运体的序列，与钠/葡萄糖共转运体基因家族相关。

Sequence of a putative transporter from rabbit kidney related to the Na+/glucose cotransporter gene family.

作者信息

Pajor A M

机构信息

Department of Physiology, University of Arizona, College of Medicine, Tucson 85724.

出版信息

Biochim Biophys Acta. 1994 Sep 14;1194(2):349-51. doi: 10.1016/0005-2736(94)90319-0.

DOI:10.1016/0005-2736(94)90319-0

PMID:7918548

Abstract

A 2 kb cDNA, RK-D, was isolated from a rabbit renal library by hybridization with the Na+/glucose cotransporter (SGLT1) cDNA. The mRNA for RK-D is also approximately 2 kb and is found predominantly in kidney. The RK-D cDNA encodes a protein of 597 amino acids related in sequence to the SGLT family of sodium-coupled transporters, all of which are related to the Na+/glucose cotransporter, SGLT1. Because of the high sequence similarity and conservation of 'signature' family features, it is very likely that RK-D encodes a Na(+)-dependent cotransporter.

摘要

通过与钠/葡萄糖协同转运蛋白（SGLT1）cDNA杂交，从兔肾文库中分离出一个2 kb的cDNA，即RK-D。RK-D的mRNA也约为2 kb，主要存在于肾脏中。RK-D cDNA编码一种由597个氨基酸组成的蛋白质，其序列与钠偶联转运蛋白的SGLT家族相关，所有这些都与钠/葡萄糖协同转运蛋白SGLT1有关。由于高度的序列相似性和“标志性”家族特征的保守性，RK-D很可能编码一种钠依赖性协同转运蛋白。