Miyazaki I, Gaedigk R, Hui M F, Cheung R K, Morkowski J, Rajotte R V, Dosch H M
Hospital for Sick Children, Department of Paediatrics, University of Toronto, Ontario, Canada.
Biochim Biophys Acta. 1994 Oct 21;1227(1-2):101-4. doi: 10.1016/0925-4439(94)90113-9.
Triggering of autoimmunity in insulin-dependent diabetes was linked to dietary bovine serum albumin (BSA). Anti-BSA antibodies from diabetes-prone rats precipitate a protein, p69, from islet cell lysates. We have used these antibodies to identify rat p69 cDNAs. Human p69 cDNA was identified by crosshybridization. The p69 coding regions show 87% nucleotide and 89% amino acid homology. Recombinant p69 is recognized by autoantibody and T cells from diabetic children.
