与西班牙有毒油综合征流行相关的油类致病性相关因素。
Factors associated with pathogenicity of oils related to the toxic oil syndrome epidemic in Spain.
作者信息
Posada de la Paz M, Philen R M, Abaitua Borda I, Diez Ruiz-Navarro M, Abraira Santos V, Pozo Rodríguez F, Pla Mestre R, Pollán Santamaría M, Sicilia Socias J M, Azpeitia Gamazo P
机构信息
Dirección General de Ordenación de la Investigación y Formación, Fondo de Investigación Sanitaria, Ministerio de Sanidad y Consumo, Madrid, Spain.
出版信息
Epidemiology. 1994 Jul;5(4):404-9. doi: 10.1097/00001648-199407000-00005.
The toxic oil syndrome (TOS), which affected over 20,000 persons in Spain in 1981, has been linked to the consumption of aniline-denatured rapeseed oil, but the precise etiologic agent is still unknown. We attempted to validate the use of high concentrations of oleyl anilide as a marker for oils that contain (or contained) the causal agent. We compared the chemical compositions of oils obtained from ill (N = 59) and unaffected (N = 70) families in 1981. Case oils had higher concentrations of fatty acids and sterols in which rapeseed oil is particularly rich. In addition, case oils had more frequent and extensive contamination with oleyl anilide and other fatty acid anilides. We observed a dose-response effect; risk increased sharply with increasing concentrations of oleyl anilide, and no control oil had more than about 825 micrograms per liter of that compound. We conclude that high concentrations of oleyl anilide specifically mark oils that contain (or used to contain) the TOS etiologic agent.
1981年在西班牙有超过20000人受到有毒油综合征（TOS）的影响，该病与食用苯胺变性菜籽油有关，但确切的致病因子仍不清楚。我们试图验证使用高浓度油酰苯胺作为含有（或曾经含有）致病因子的油类标志物的有效性。我们比较了1981年从患病家庭（N = 59）和未受影响家庭（N = 70）获取的油类的化学成分。病例油中脂肪酸和甾醇的浓度较高，而菜籽油中这些成分尤其丰富。此外，病例油中油酰苯胺和其他脂肪酸苯胺的污染更频繁且更广泛。我们观察到了剂量反应效应；随着油酰苯胺浓度的增加，风险急剧上升，并且对照油中该化合物的含量均不超过每升约825微克。我们得出结论，高浓度的油酰苯胺可特异性地标记含有（或曾经含有）有毒油综合征致病因子的油类。
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