Posada de la Paz M, Philen R M, Schurz H, Hill R H, Giménez Ribota O, Gómez de la Camara A, Kilbourne E M, Abaitua I
Instituto de Salud Carlos III, Subdirección General de Epidemiología e Información Sanitaria, Centro de Investigación para el Síndrome del Aceite Tóxico, Ministerio de Sanidad y Consumo, Madrid, Spain.
Epidemiology. 1999 Mar;10(2):130-4.
Toxic oil syndrome appeared in epidemic form in Spain in 1981. Epidemiologic studies have demonstrated that illness was caused by consumption of rapeseed oil that had been denatured with aniline. Chemical analyses of oil specimens conducted in conjunction with epidemiologic studies have established that consumption of specific oils containing fatty acid anilide contaminants was associated with increased risk for disease. New chemical analytic methods identified a family of compounds, the di-fatty acid esters of phenylamino propane-diol, and one of these compounds, the 1,2-di-oleyl ester of 3-(N-phenylamino)-1,2-propanediol (DPAP), has been found to be more strongly associated with disease status than the fatty acid anilides. We found the odds ratio for exposure to DPAP (OR = 26.4, 95% CI = 6.4-76.3) is much higher than the odds ratio for exposure to oleyl anilide (OR = 4.1, 95% CI = 2.2-7.8), implying that exposure to DPAP was a more relevant risk factor for development of toxic oil syndrome than exposure to oleyl anilide. In this paper, we review and present analyses of data from multiple studies of the possible etiologic role of DPAP in toxic oil syndrome. The presence of DPAP in oil collected from affected and unaffected households was a more specific correlate of case relatedness than was the presence of fatty acid anilides, and it was equally sensitive. Moreover, DPAP was found in oil from the only refinery whose oil was clearly associated with illness.
1981年，中毒性油综合征在西班牙以流行形式出现。流行病学研究表明，该病是由食用用苯胺变性的菜籽油引起的。与流行病学研究相结合对油样进行的化学分析证实，食用含有脂肪酸苯胺污染物的特定油类会增加患病风险。新的化学分析方法鉴定出了一类化合物，即苯氨基丙二醇的二脂肪酸酯，其中一种化合物，3-(N-苯氨基)-1,2-丙二醇的1,2-二油基酯（DPAP），被发现与疾病状态的关联比脂肪酸苯胺更强。我们发现，接触DPAP的比值比（OR = 26.4，95%CI = 6.4 - 76.3）远高于接触油基苯胺的比值比（OR = 4.1，95%CI = 2.2 - 7.8），这意味着与接触油基苯胺相比，接触DPAP是中毒性油综合征发病更相关的危险因素。在本文中，我们回顾并展示了来自多项研究的数据分析，这些研究探讨了DPAP在中毒性油综合征中可能的病因作用。与脂肪酸苯胺的存在相比，从受影响和未受影响家庭收集的油中DPAP的存在与病例相关性更具特异性，且敏感性相同。此外，在唯一一家其油与疾病明显相关的炼油厂的油中发现了DPAP。
