Harguindey S
Servicio de Oncología Médica, Clínica La Esperanza, Vitoria.
An Med Interna. 1994 Jun;11(6):299-303.
A systematic outlook of metabolism regarding the strategy followed by cancer cells is necessary in order to understand the thermodynamic advantages of these cells and the difficulty found in the treatment of certain malignant diseases. These features show that the present-day vision, the biochemical-analytical-fragmentary-reduccionistic approach, is not and it is not likely that it wil never be sufficient. Thus, a new paradigm of a different dimension but a the same time complementary to the previous and actual one seems necessary. Therefore, a higher and more comprehensive and outreaching vision, transbiochemical and metaenzymatic, one ecologically and macro and microenvironmentally oriented and finally synthetic and unitary one, appears mandatory. The dynamics of the hydrogen ion as applied to biological processes seems to be able to offer the opportunity to arrive to such kind of unifying comprehension through an integrated perceptive model at multiple levels of biological, biomedical and biophysical understanding.
为了理解癌细胞所采用策略的代谢系统观点，以及这些细胞的热力学优势和某些恶性疾病治疗中所面临的困难，这是必要的。这些特征表明，当今的观点，即生化分析的、零碎的、还原论的方法，现在不够，而且很可能永远都不够。因此，似乎需要一种不同维度但同时又与先前和当前方法互补的新范式。所以，一种更高、更全面、更具前瞻性的观点，即跨生化和元酶的观点，一种生态、宏观和微观环境导向的观点，最终是综合统一的观点，显得必不可少。应用于生物过程的氢离子动力学似乎能够通过一个在生物、生物医学和生物物理理解的多个层面上的综合感知模型，提供达成这种统一理解的机会。
