Harguindey S
Servicio de Oncología, Clínica La Esperanza, Vitoria.
An Med Interna. 1994 Jul;11(7):351-8.
The metabolic and biochemical program of neoplastic cells regarding carbohydrate metabolism can be extend to the rest of the metabolism. This gives a rational idea of the global strategy and thermodynamic advantages of malignant cells and of tumors in general as related to the host. A comprehensive, metaenzymatic and transbiochemical approach allows to understand some of the reasons for the limitations found along the last decades by the different chemotherapeutic attempts directed against particular enzymes overexpressed in tumor cells. This indicates that a new vision of the whole problem is preceptive. The overwhelming effects of the hydrogen ion at multiple levels indicates that an initial approach based upon this unifying principle and universal regulatory parameter may provide the initial codes, hints and hunches, of a new synthetic and unitive biological, biomedical and biophysical scientific paradigm. Initially, it already offers the possibility of a new multidisciplinary approach to the prevention and treatment of tumors such as cervical intraepitelial neoplasia.
肿瘤细胞在碳水化合物代谢方面的代谢和生化程序可以扩展到其他代谢过程。这为恶性细胞和肿瘤总体上相对于宿主的全局策略和热力学优势提供了合理的概念。一种全面的、元酶促和跨生化方法有助于理解过去几十年来针对肿瘤细胞中过表达的特定酶进行的不同化疗尝试所发现的局限性的一些原因。这表明对整个问题要有新的认识。氢离子在多个层面的压倒性作用表明,基于这一统一原则和通用调节参数的初步方法可能提供新的合成性和综合性生物学、生物医学和生物物理科学范式的初始代码、线索和直觉。最初,它已经为诸如宫颈上皮内瘤变等肿瘤的预防和治疗提供了新的多学科方法的可能性。