Antigen-antibody recognition. Model calculations.
作者信息
Nauchitel V V, Somorjai R L
机构信息
Oklahoma University Health Sciences Center, Oklahoma City 73190.
出版信息
Biophys Chem. 1994 Aug;51(2-3):337-47. doi: 10.1016/0301-4622(94)00054-9.
PMID:7919042
Abstract
Free energy of antigen-antibody binding has been calculated for HyHEL-5, HyHEL-10, and D1.3 complexes. We also have calculated free energies of binding per residue of L- and H- chains of the antibodies, and those of the antigen (lysozyme). The results of the calculations provide support for the notion that TYR and TRP residues may confer on the CDRs of antibodies an enhanced capacity for binding antigens. It was shown also that the composition of residues that provide major part of the binding free energy differs for antibodies and antigens.
摘要
相似文献
1
Antigen-antibody recognition. Model calculations.
Biophys Chem. 1994 Aug;51(2-3):337-47. doi: 10.1016/0301-4622(94)00054-9.
2
Three-dimensional structures of the free and antigen-bound Fab from monoclonal antilysozyme antibody HyHEL-63(,).来自单克隆抗溶菌酶抗体HyHEL-63的游离Fab片段和抗原结合Fab片段的三维结构(,)。
Biochemistry. 2000 May 30;39(21):6296-309. doi: 10.1021/bi000054l.
3
Dissection of binding interactions in the complex between the anti-lysozyme antibody HyHEL-63 and its antigen.抗溶菌酶抗体HyHEL-63与其抗原复合物中结合相互作用的剖析
Biochemistry. 2003 Jan 14;42(1):11-22. doi: 10.1021/bi020589+.
4
Induced peptide conformations in different antibody complexes: molecular modeling of the three-dimensional structure of peptide-antibody complexes using NMR-derived distance restraints.不同抗体复合物中诱导的肽构象：利用核磁共振衍生的距离限制对肽-抗体复合物三维结构进行分子建模。
Biochemistry. 1992 Aug 4;31(30):6884-97. doi: 10.1021/bi00145a004.
5
Three-dimensional structures of the free and the antigen-complexed Fab from monoclonal anti-lysozyme antibody D44.1.来自单克隆抗溶菌酶抗体D44.1的游离Fab片段及与抗原结合的Fab片段的三维结构。
J Mol Biol. 1994 Nov 4;243(4):767-81. doi: 10.1016/0022-2836(94)90046-9.
6
Global changes in amide hydrogen exchange rates for a protein antigen in complex with three different antibodies.
J Mol Biol. 1996 Apr 12;257(4):866-76. doi: 10.1006/jmbi.1996.0207.
7
On the attribution of binding energy in antigen-antibody complexes McPC 603, D1.3, and HyHEL-5.关于抗原-抗体复合物McPC 603、D1.3和HyHEL-5中结合能的归属
Biochemistry. 1989 May 30;28(11):4735-49. doi: 10.1021/bi00437a034.
8
Refined structures of bobwhite quail lysozyme uncomplexed and complexed with the HyHEL-5 Fab fragment.未与HyHEL-5 Fab片段结合及结合后的北美鹑溶菌酶的精细结构。
Proteins. 1996 Sep;26(1):55-65. doi: 10.1002/(SICI)1097-0134(199609)26:1<55::AID-PROT5>3.0.CO;2-F.
9
Structural consequences of mutations in interfacial Tyr residues of a protein antigen-antibody complex. The case of HyHEL-10-HEL.蛋白质抗原-抗体复合物界面酪氨酸残基突变的结构后果。HyHEL-10-HEL的案例
J Biol Chem. 2007 Mar 2;282(9):6783-91. doi: 10.1074/jbc.M605197200. Epub 2006 Dec 12.
10
Free energy simulations of the HyHEL-10/HEL antibody-antigen complex.
Protein Eng. 1995 Jul;8(7):663-75. doi: 10.1093/protein/8.7.663.
Zotero 插件