Oz F, Urgancioglu I, Uslu I, Dervisoglu S, Oz B, Kanmaz B
Pathology Department, Cerrahpasa Medical School, Istanbul, Turkey.
Cytopathology. 1994 Jun;5(3):154-63. doi: 10.1111/j.1365-2303.1994.tb00411.x.
Cytological changes in the thyroid glands of 120 patients who had received 131I treatment for hyperthyroidism were examined in detail. The cytological material was obtained by fine needle aspiration cytology. The patients were divided into four groups according to the amount of time elapsed after the 131I treatment. The control groups were selected from euthyroid patients with hypoactive or non-functional solitary nodules and patients with Graves' disease who had not received 131I therapy. The thyrocytes revealed degenerative changes in the immediate period after cessation of treatment. One year after the treatment some non-specific changes, such as oxyphilic metaplasia and regeneration, were seen. No malignant change has been observed clinically or cytologically during up to 20 years of follow up since receiving 131I.
对120例因甲亢接受131I治疗的患者的甲状腺细胞学变化进行了详细检查。细胞学材料通过细针穿刺细胞学获得。根据131I治疗后经过的时间，将患者分为四组。对照组选自甲状腺功能减退或无功能的孤立性结节的甲状腺功能正常患者以及未接受131I治疗的格雷夫斯病患者。治疗停止后的即刻，甲状腺细胞出现退行性变化。治疗一年后，可见一些非特异性变化，如嗜酸性化生和再生。自接受131I治疗以来，在长达20年的随访中，未观察到临床或细胞学上的恶性变化。
