Abreu P, Llorente E, Hernández M M, González M C
Department of Physiology, School of Medicine, University of La Laguna, Tenerife, Spain.
Neuroreport. 1994 Jun 27;5(11):1356-8.
The effects of intracerebroventricularly (i.c.v.) injected interleukin-1 beta (IL-1 beta) on tyrosine hydroxylase (TH) activity in the median eminence and on serum adrenocorticotropin hormone (ACTH) and prolactin (PRL) levels were studied in freely moving male rats chronically implanted with i.c.v. cannulas. IL-1 beta stimulated TH activity of the median eminence in a dose-dependent manner. Intracerebroventricular injections of 100 ng and 200 ng IL-1 beta significantly increased TH activity in the median eminence by 40.6% and 74.7% respectively over the saline-injected control group. The stimulation of ACTH secretion was statistically significant for all doses used, however i.c.v. injections of IL-1 beta failed to elicit significant changes in the serum PRL concentrations. These results suggest that IL-1 beta increases dopaminergic activity of the medial basal hypothalamus to produce its neuroendocrine effects.
在长期植入脑室内插管的自由活动雄性大鼠中，研究了脑室内注射白细胞介素-1β（IL-1β）对正中隆起中酪氨酸羟化酶（TH）活性以及血清促肾上腺皮质激素（ACTH）和催乳素（PRL）水平的影响。IL-1β以剂量依赖的方式刺激正中隆起的TH活性。与注射生理盐水的对照组相比，脑室内注射100 ng和200 ng IL-1β分别使正中隆起的TH活性显著增加40.6%和74.7%。所用的所有剂量对ACTH分泌的刺激均具有统计学意义，然而脑室内注射IL-1β未能引起血清PRL浓度的显著变化。这些结果表明，IL-1β增加下丘脑内侧基底部的多巴胺能活性以产生其神经内分泌效应。
