Hizawa N, Kojima J, Kojima T, Sukoh N, Yamaguchi E, Kawakami Y, Matsushima T
First Department of Medicine, Hokkaido University, Sapporo.
Intern Med. 1994 Jun;33(6):337-41. doi: 10.2169/internalmedicine.33.337.
Following a three-week administration of alpha-interferon (IFN-alpha), a 62-year-old woman with chronic hepatitis C manifested fever and dyspnea and showed diffuse infiltrative opacities on chest roentgenograms. Her laboratory data included results of anemia with reticulocytosis, a decreased complement level and hepatitis with elevated ALP, LDH and gamma-GTP. Because laboratory data also revealed a positive lymphocyte stimulation test for IFN-alpha, this cytokine was considered to be responsible for the development of interstitial pneumonia, hemolytic anemia and cholestatic liver dysfunction due to its immunomodulatory effects. Although these three disorders have been reported to develop singly after IFN-alpha therapy, this is the first report of a patient in whom these disorders occurred simultaneously.
在给予α-干扰素（IFN-α）三周后，一名62岁的慢性丙型肝炎女性出现发热和呼吸困难，胸部X线片显示弥漫性浸润性阴影。她的实验室检查结果包括伴有网织红细胞增多的贫血、补体水平降低以及伴有碱性磷酸酶（ALP）、乳酸脱氢酶（LDH）和γ-谷氨酰转肽酶（γ-GTP）升高的肝炎。由于实验室检查还显示针对IFN-α的淋巴细胞刺激试验呈阳性，这种细胞因子因其免疫调节作用被认为是间质性肺炎、溶血性贫血和胆汁淤积性肝功能障碍发生的原因。虽然这三种疾病在IFN-α治疗后单独发生的情况已有报道，但这是首例这三种疾病同时发生的患者报告。
