Nakajima M, Kubota Y, Miyashita N, Niki Y, Matsushima T, Manabe T
Department of Internal Medicine, Kawasaki Medical School, Kurashiki.
Intern Med. 1996 May;35(5):376-9. doi: 10.2169/internalmedicine.35.376.
We report a 67-year-old male patient with a known history of sarcoidosis in remission who had recurrent sarcoidosis following a five-month administration of interferon alpha (IFN-alpha) for chronic hepatitis C. He developed bilateral swelling of the parotid glands and bilateral diffuse reticulonodular pulmonary parenchymal opacities on chest roentgenograms. Serum angiotensin converting enzyme (ACE) levels and soluble IL-2 receptor levels were high and a transbronchial lung biopsy revealed noncaseating granulomas. The abnormalities on both laboratory data and chest roentgenograms were resolved after administration of oral prednisolone.
我们报告了一名67岁男性患者，有结节病病史，目前处于缓解期，在接受干扰素α（IFN-α）治疗慢性丙型肝炎5个月后出现结节病复发。他出现双侧腮腺肿大，胸部X线片显示双侧弥漫性网状结节状肺实质混浊。血清血管紧张素转换酶（ACE）水平和可溶性白细胞介素-2受体水平升高，经支气管肺活检显示非干酪样肉芽肿。口服泼尼松龙后，实验室检查数据和胸部X线片上的异常均得到缓解。
