Suchner U, Senftleben U
Institut für Anaesthesiologie, Ludwig-Maximilians-Universität, Klinikum Grosshadern, München.
Infusionsther Transfusionsmed. 1994 Jun;21(3):167-82. doi: 10.1159/000222968.
Review of the range of action of polyunsaturated fatty acids (PUFAs) on the basis of interactions with eicosanoids. Discussion of the clinical relevance of these actions.
Original papers and reviews of the pertinent literature in German and English, covered by repeated MEDLINE searchers.
Pertinent original papers and review articles from 1983 on, as well as some significant original papers of earlier origin with main emphasis on studies concerned with the pharmacodynamic interactions between PUFAs, eicosanoids and the immune system.
PUFAs are precursors of eicosanoid formation. Interactions between PUFAs and the immune system are influenced by the rate of synthesis as well as by the efficacy of the various eicosanoids. The rate of eicosanoid synthesis is determined by PUFA turnover. In the absence of essential fatty acid deficiency (EFAD), PUFA turnover depends on the activity of phospholipases. Activities are enhanced under the influence of stress factors such as trauma and sepsis. The efficacy of eicosanoids is determined by the availability of different PUFAs in the cellular phospholipid pool, whereby n-6 and n-3 PUFAs give rise to eicosanoids of different series. The eicosanoids formed from n-3 PUFAs, compared to those derived from n-6 PUFAs, develop similar quality but less intensity of action. Therefore, eicosanoids of different origin induce different effects at a given rate of synthesis.
Appropriate dietary alterations of the availability of n-6 and n-3 PUFAs together with the resulting influence on synthesis and action of mediators, possibly might serve as a pharmacological tool to influence systemic functions in critically ill patients in the future.
基于多不饱和脂肪酸（PUFAs）与类花生酸的相互作用，综述其作用范围。讨论这些作用的临床相关性。
通过多次MEDLINE检索，获取德语和英语相关文献的原始论文及综述。
1983年以来的相关原始论文和综述文章，以及一些早期的重要原始论文，主要侧重于PUFAs、类花生酸与免疫系统之间药效学相互作用的研究。
PUFAs是类花生酸形成的前体。PUFAs与免疫系统之间的相互作用受合成速率以及各种类花生酸效力的影响。类花生酸的合成速率由PUFA周转决定。在不存在必需脂肪酸缺乏（EFAD）的情况下，PUFA周转取决于磷脂酶的活性。在创伤和脓毒症等应激因素的影响下，活性会增强。类花生酸的效力由细胞磷脂池中不同PUFAs的可用性决定，其中n-6和n-3 PUFAs会产生不同系列的类花生酸。与源自n-6 PUFAs的类花生酸相比，由n-3 PUFAs形成的类花生酸具有相似的性质，但作用强度较小。因此，不同来源的类花生酸在给定的合成速率下会产生不同的效应。
适当调整饮食中n-6和n-3 PUFAs的供应量，以及由此对介质合成和作用产生的影响，可能在未来作为一种药理学工具来影响危重病患者的全身功能。
