Conley M E
Department of Pediatrics, University of Tennessee College of Medicine, St Jude Children's Research Hospital, Memphis 38105.
Curr Opin Genet Dev. 1994 Jun;4(3):401-6. doi: 10.1016/0959-437x(94)90028-0.
In the past year, researchers have identified the genes responsible for X-linked severe combined immunodeficiency (encoding a cytokine receptor protein), X-linked agammaglobulinemia (encoding a cytoplasmic tyrosine kinase) and X-linked hyper IgM syndrome (encoding the ligand for CD40). Although these three genes are completely unrelated, it is of interest that all are lineage-specific genes that are involved in the control of lymphocyte proliferation or differentiation.
