McCleskey E W
Vollum Institute, Oregon Health Science University, Portland 97201.
Curr Opin Neurobiol. 1994 Jun;4(3):304-12. doi: 10.1016/0959-4388(94)90090-6.
An unexpected variety of different types of Ca2+ channels have been identified using molecular cloning and selective Ca2+ channel toxins. A main focus of current research in this field is to characterize these different channel types and the molecular mechanisms by which Ca2+ channels perform their basic activities of gating, selectivity and modulation. Recent advances demonstrate the roles of different types of Ca2+ channels in muscle and nerve, and provide hints about the structures involved in selectivity and gating.
通过分子克隆和选择性钙通道毒素，人们已经鉴定出了种类意想不到的不同类型的钙通道。该领域当前研究的一个主要重点是表征这些不同的通道类型以及钙通道执行其门控、选择性和调节等基本活动的分子机制。最近的进展揭示了不同类型的钙通道在肌肉和神经中的作用，并提供了有关参与选择性和门控的结构的线索。
