甲状腺功能亢进或减退患者治疗期间的血清III型前胶原氨基端前肽

Serum amino-terminal propeptide of type III procollagen in patients with hyperthyroidism or hypothyroidism during therapy.

作者信息

Kucharz E J, Jurecka-Tuleja B, Jonderko G, Marcisz C

机构信息

Fourth Department of Internal Medicine, Silesian University School of Medicine, Tychy, Poland.

出版信息

Thyroid. 1994 Summer;4(2):191-4. doi: 10.1089/thy.1994.4.191.

DOI:10.1089/thy.1994.4.191

PMID:7920002

Abstract

Changes in serum amino-terminal type III procollagen propeptide (PIIIPN) and hydroxyproline were compared with indices of thyroid function in 33 patients with hyperthyroidism and 16 patients with hypothyroidism before and after treatment. Control values were obtained from 26 healthy individuals. Hyperthyroidism was shown to be associated with an increased level of PIIIPN and hypothyroidism with a decreased PIIIPN level. An increase in PIIIPN was found in 100% of hyperthyroid patients and a decrease in 31% of those with hypothyroidism, while hydroxyproline increased in only 54% of patients with hyperthyroidism and its level was decreased in only 6% of patients with hypothyroidism. Correlation between PIIIPN and thyroxine and triiodothyronine levels was shown. The results obtained suggest that PIIIPN is a valuable index of tissue response to thyroid hormones.

摘要

比较了33例甲状腺功能亢进患者和16例甲状腺功能减退患者治疗前后血清Ⅲ型前胶原氨基端前肽（PIIIPN）和羟脯氨酸的变化与甲状腺功能指标。对照组数据来自26名健康个体。结果显示，甲状腺功能亢进与PIIIPN水平升高有关，甲状腺功能减退与PIIIPN水平降低有关。100%的甲状腺功能亢进患者PIIIPN升高，31%的甲状腺功能减退患者PIIIPN降低，而羟脯氨酸仅在54%的甲状腺功能亢进患者中升高，仅6%的甲状腺功能减退患者其水平降低。显示了PIIIPN与甲状腺素和三碘甲状腺原氨酸水平之间的相关性。所得结果表明，PIIIPN是组织对甲状腺激素反应的一个有价值的指标。