Kohno M, Murakawa K, Yasunari K, Nishizawa Y, Morii H, Takeda T
First Department of Internal Medicine, Osaka City University Medical School, Japan.
Am J Med. 1987 Oct;83(4):648-52. doi: 10.1016/0002-9343(87)90893-x.
Plasma concentrations of atrial natriuretic peptides were measured in 32 normal control subjects, 25 patients with hyperthyroidism, and 18 patients with hypothyroidism. Atrial natriuretic peptide values were measured before and after successful therapy with methimazole or 1-thyroxine. Plasma atrial natriuretic peptide concentration was increased in patients with hyperthyroidism (48.0 +/- 19.5 pg/ml) but was decreased in patients with severe hypothyroidism (16.3 +/- 5.7 pg/ml) compared with values in normal control subjects (31.2 +/- 9.5 pg/ml). There was no significant difference between values in normal control subjects and mildly hypothyroid patients (35.0 +/- 12.2 pg/ml). The plasma atrial natriuretic peptide concentration was correlated with the serum thyroxine level and heart rate. The elevated atrial natriuretic peptide concentration in hyperthyroidism decreased, whereas the reduced atrial natriuretic peptide concentration in severe hypothyroidism increased, compared with the initial value after successful therapy. These results suggest that plasma atrial natriuretic peptide concentration is frequently increased in hyperthyroidism and is frequently decreased in severe hypothyroidism, and that thyroid hormone is one of the regulatory factors for circulating atrial natriuretic peptides.
对32名正常对照者、25名甲状腺功能亢进患者和18名甲状腺功能减退患者测定了血浆心钠素浓度。在用甲巯咪唑或左甲状腺素成功治疗前后测定心钠素值。与正常对照者（31.2±9.5 pg/ml）相比，甲状腺功能亢进患者的血浆心钠素浓度升高（48.0±19.5 pg/ml），而重度甲状腺功能减退患者的血浆心钠素浓度降低（16.3±5.7 pg/ml）。正常对照者与轻度甲状腺功能减退患者的值（35.0±12.2 pg/ml）之间无显著差异。血浆心钠素浓度与血清甲状腺素水平及心率相关。与成功治疗后的初始值相比，甲状腺功能亢进时升高的心钠素浓度降低，而重度甲状腺功能减退时降低的心钠素浓度升高。这些结果提示，血浆心钠素浓度在甲状腺功能亢进时常常升高，在重度甲状腺功能减退时常常降低，且甲状腺激素是循环中心钠素的调节因子之一。
