Bosch F X, Muñoz N, de Sanjosé S, Guerrerro E, Ghaffari A M, Kaldor J, Castellsagué X, Shah K V
Sevei d'Epidemiologia i Registre del Càncer, Ciutat Sanitària, Barcelona, Spain.
Cancer Epidemiol Biomarkers Prev. 1994 Jul-Aug;3(5):375-9.
The risk of cervical cancer for a woman depends largely on the probability of being infected with some specific types of Human Papillomavirus (HPV). In the control groups of four case-control studies in Colombia and Spain we have shown a strong correlation between the number of sexual partners of males and females and HPV DNA prevalence in the genital tract. Our results suggest that the lifetime number of sexual partners in both sexes are surrogates of the probability of HPV infection and, as such, insufficiently explain the geographical variation in the incidence of cervical cancer. It is proposed that the high rates of cervical cancer in Latin America are linked to the largely unknown characteristics of the HPV endemicity in the population and to the absence of widespread screening for cervical neoplasia. Reliable surveys on the HPV prevalences in selected social groups (i.e., young males and prostitutes) as well as in populations in countries at different risk of cervical cancer are required.
女性患宫颈癌的风险很大程度上取决于感染某些特定类型人乳头瘤病毒（HPV）的概率。在哥伦比亚和西班牙的四项病例对照研究的对照组中，我们发现男性和女性性伴侣数量与生殖道HPV DNA流行率之间存在很强的相关性。我们的研究结果表明，男女的终身性伴侣数量是HPV感染概率的替代指标，因此，不足以解释宫颈癌发病率的地理差异。有人提出，拉丁美洲宫颈癌的高发病率与人群中HPV流行的很大程度上未知的特征以及缺乏对宫颈肿瘤的广泛筛查有关。需要对选定社会群体（即年轻男性和妓女）以及处于不同宫颈癌风险国家的人群中的HPV流行率进行可靠调查。
