Witzig T E, Weitz J J, Lundberg J H, Tefferi A
Division of Internal Medicine and Hematology, Mayo Clinic, Rochester, Minnesota 55905.
Leuk Lymphoma. 1994 Jun;14(1-2):137-9. doi: 10.3109/10428199409049659.
This report describes two cases of T-cell chronic lymphocytic leukemia (T-CLL) treated with purine nucleoside analogues. One patient had CD8+, CD3+ large granular lymphocytosis (LGL) producing transfusion-dependent anemia and was refractory to chemotherapy. Treatment with four cycles of fludarabine produced a clinical complete remission and a molecular genetic partial remission that has been durable for > 15 months. The other patient had CD4+ T-prolymphocytic leukemia and was unresponsive to both fludarabine and 2-chlorodeoxyadenosine. Further trials of these agents are warranted in T-CLL, especially the LGL variant.
本报告描述了两例接受嘌呤核苷类似物治疗的T细胞慢性淋巴细胞白血病（T-CLL）病例。一名患者患有CD8 +、CD3 +大颗粒淋巴细胞增多症（LGL），导致依赖输血的贫血，并且对化疗耐药。四个周期的氟达拉滨治疗产生了临床完全缓解和持续超过15个月的分子遗传学部分缓解。另一名患者患有CD4 + T原淋巴细胞白血病，对氟达拉滨和2-氯脱氧腺苷均无反应。有必要在T-CLL，尤其是LGL变异型中对这些药物进行进一步试验。
