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与异常胆固醇代谢相关的遗传性疾病的生化研究。I. 脑腱性黄瘤病中胆汁醇葡萄糖醛酸苷的高效液相色谱分析。

Biochemical studies of inherited diseases related to abnormal cholesterol metabolism. I. High-performance liquid chromatographic analysis of bile alcohol glucuronides in cerebrotendinous xanthomatosis.

作者信息

Ohshima A, Kuramoto T, Hoshita T

机构信息

Department of Surgery 1, Kyushu University School of Medicine, Fukuoka, Japan.

出版信息

Biol Pharm Bull. 1994 May;17(5):721-3. doi: 10.1248/bpb.17.721.

DOI:10.1248/bpb.17.721
PMID:7920441
Abstract

We developed a rapid and simple quantitative method for measuring bile alcohol glucuronides in serum involving high-performance liquid chromatography without group separation and hydrolysis. The assay of 5 beta-cholestane-3 alpha,7 alpha,12 alpha,25-tetrol 3-glucuronide, the major bile alcohol component in serum from cerebrotendinous xanthomatosis patients, with the present method was useful for the diagnosis of cerebrotendinous xanthomatosis.

摘要

我们开发了一种快速简便的定量方法，用于测量血清中的胆汁醇葡糖醛酸苷，该方法采用高效液相色谱法，无需进行基团分离和水解。采用本方法测定脑腱黄瘤病患者血清中主要胆汁醇成分5β-胆甾烷-3α,7α,12α,25-四醇3-葡糖醛酸苷，对脑腱黄瘤病的诊断有帮助。

相似文献

1
Biochemical studies of inherited diseases related to abnormal cholesterol metabolism. I. High-performance liquid chromatographic analysis of bile alcohol glucuronides in cerebrotendinous xanthomatosis.与异常胆固醇代谢相关的遗传性疾病的生化研究。I. 脑腱性黄瘤病中胆汁醇葡萄糖醛酸苷的高效液相色谱分析。
Biol Pharm Bull. 1994 May;17(5):721-3. doi: 10.1248/bpb.17.721.
2
Increased plasma bile alcohol glucuronides in patients with cerebrotendinous xanthomatosis: effect of chenodeoxycholic acid.脑腱黄瘤病患者血浆胆汁醇葡萄糖醛酸苷水平升高：鹅去氧胆酸的作用
J Lipid Res. 1987 Aug;28(8):1006-12.
3
Cerebrotendinous xanthomatosis: a review of biochemical findings of the patient population in The Netherlands.脑腱黄瘤病：荷兰患者群体的生化检查结果综述
J Inherit Metab Dis. 1988;11(1):56-75. doi: 10.1007/BF01800057.
4
Radioimmunoassay of 5 beta-cholestane-3 alpha,7 alpha,12 alpha,25-tetrol 3-glucuronide in serum of patients with cerebrotendinous xanthomatosis.脑腱黄瘤病患者血清中5β-胆甾烷-3α,7α,12α,25-四醇3-葡萄糖醛酸苷的放射免疫测定
Steroids. 1992 Jan;57(1):32-6. doi: 10.1016/0039-128x(92)90093-o.
5
Determination of the glucurono-conjugated position in bile alcohol glucuronides present in a patient with cerebrotendinous xanthomatosis.
Steroids. 1995 Oct;60(10):709-12. doi: 10.1016/0039-128x(95)00095-8.
6
Use of positive ion fast atom bombardment mass spectrometry for rapid identification of a bile alcohol glucuronide isolated from cerebrotendinous xanthomatosis patients.
Steroids. 1990 Feb;55(2):74-8. doi: 10.1016/0039-128x(90)90028-a.
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Occurrence of bile alcohol glucuronides in bile of patients with cerebrotendinous xanthomatosis.脑腱黄瘤病患者胆汁中胆汁醇葡萄糖醛酸苷的出现情况。
J Lipid Res. 1980 Nov;21(8):1015-21.
8
Serum bile acid profiles in cerebrotendinous xanthomatosis.脑腱黄瘤病患者的血清胆汁酸谱
Clin Chim Acta. 1982 Feb 5;118(2-3):167-75. doi: 10.1016/0009-8981(82)90004-3.
9
Determination of the glucurono-conjugated position in bile alcohol glucuronides excreted in urine of a patient with cerebrotendinous xanthomatosis by a nuclear magnetic resonance study.通过核磁共振研究确定脑腱性黄瘤病患者尿液中排泄的胆汁醇葡萄糖醛酸苷的葡萄糖醛酸结合位置。
J Biochem. 1994 Apr;115(4):655-8. doi: 10.1093/oxfordjournals.jbchem.a124391.
10
Bile alcohol profiles in bile, urine, and feces of a patient with cerebrotendinous xanthomatosis.脑腱黄瘤病患者胆汁、尿液和粪便中的胆汁醇谱。
J Biochem. 1986 Feb;99(2):477-83. doi: 10.1093/oxfordjournals.jbchem.a135502.