与异常胆固醇代谢相关的遗传性疾病的生化研究。I. 脑腱性黄瘤病中胆汁醇葡萄糖醛酸苷的高效液相色谱分析。
Biochemical studies of inherited diseases related to abnormal cholesterol metabolism. I. High-performance liquid chromatographic analysis of bile alcohol glucuronides in cerebrotendinous xanthomatosis.
作者信息
Ohshima A, Kuramoto T, Hoshita T
机构信息
Department of Surgery 1, Kyushu University School of Medicine, Fukuoka, Japan.
出版信息
Biol Pharm Bull. 1994 May;17(5):721-3. doi: 10.1248/bpb.17.721.
PMID:7920441
Abstract
We developed a rapid and simple quantitative method for measuring bile alcohol glucuronides in serum involving high-performance liquid chromatography without group separation and hydrolysis. The assay of 5 beta-cholestane-3 alpha,7 alpha,12 alpha,25-tetrol 3-glucuronide, the major bile alcohol component in serum from cerebrotendinous xanthomatosis patients, with the present method was useful for the diagnosis of cerebrotendinous xanthomatosis.
摘要
我们开发了一种快速简便的定量方法，用于测量血清中的胆汁醇葡糖醛酸苷，该方法采用高效液相色谱法，无需进行基团分离和水解。采用本方法测定脑腱黄瘤病患者血清中主要胆汁醇成分5β-胆甾烷-3α,7α,12α,25-四醇3-葡糖醛酸苷，对脑腱黄瘤病的诊断有帮助。
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