Nakajima O, Sugishita Y, Hashimoto Y, Iwasaki S
Institute of Molecular and Cellular Biosciences, University of Tokyo, Japan.
Biol Pharm Bull. 1994 May;17(5):742-4. doi: 10.1248/bpb.17.742.
The effect of various structural/functional tubulin disruptors (including colchicine-type disruptors, vinblastine, rhizoxin, maytansine, peptide-type disruptors, and taxol) on the chemically induced differentiation of human leukemia cell lines (HL-60 and K562) was examined. As differentiation-inducing agents, 12-O-tetradecanoylphorbol-13-acetate (TPA) was used for the differentiation of both HL-60 and K562 to monocyte/macrophages, retinoids were used for the differentiation of HL-60 to mature granulocytes, and hemin was used for the erythroid differentiation of K562. All the tubulin disruptors investigated increased the chemically-induced differentiation of HL-60 and K562 cell lines to the cognate mature cell types, regardless of the nature of the differentiation.
