Nakajima O, Hashimoto Y, Iwasaki S
Institute of Molecular and Cellular Biosciences, University of Tokyo, Japan.
FEBS Lett. 1993 Sep 6;330(1):81-4. doi: 10.1016/0014-5793(93)80924-j.
The effect of retinoid on human leukemia K562 cell differentiation induced by hemin was examined. Retinoids (retinoic acid and synthetic retinoids [Am80 and Ch55]) dose-dependently enhanced hemin-induced erythroid differentiation of K562 cells, though these retinoids themselves did not induce the differentiation. Under optimal conditions, these retinoids caused a doubling of the population of hemin-induced differentiated cells. In addition, co-treatment of cells with hemin and retinoid led to longer maintenance of the differentiated state after the removal of hemin, which might imply acquisition of irreversibility of hemin-induced differentiation. These results suggest that the combination of retinoids with other differentiation inducers might be useful for leukemia therapy in cases where the leukemic cells are poorly responsive or unresponsive to retinoids, alone.
研究了类视黄醇对氯化血红素诱导的人白血病K562细胞分化的影响。类视黄醇（视黄酸和合成类视黄醇[Am80和Ch55]）剂量依赖性地增强了氯化血红素诱导的K562细胞的红系分化，尽管这些类视黄醇本身并不诱导分化。在最佳条件下，这些类视黄醇使氯化血红素诱导的分化细胞数量增加了一倍。此外，用氯化血红素和类视黄醇共同处理细胞导致去除氯化血红素后分化状态的维持时间更长，这可能意味着氯化血红素诱导的分化获得了不可逆性。这些结果表明，在白血病细胞对类视黄醇单独反应不佳或无反应的情况下，类视黄醇与其他分化诱导剂的联合使用可能对白血病治疗有用。
