Herrmann B G, Kispert A
Max-Planck Institut für Entwicklungsbiologie, Abteilung Biochemie, Tübingen, Germany.
Trends Genet. 1994 Aug;10(8):280-6. doi: 10.1016/0168-9525(90)90011-t.
Since its identification in 1927, the mouse T (Brachyury) locus has been implicated in mesoderm formation and notochord differentiation. Recent work has demonstrated that this gene encodes a putative transcription factor expressed specifically in nascent mesoderm and in the differentiating notochord. Homologous genes have been cloned from the frog Xenopus laevis, the zebrafish Brachydanio rerio and the ascidian Halocynthia roretzi. The T gene is an important tool for elucidating mesoderman and embryonic pattern formation.
自1927年被鉴定以来，小鼠T（短尾）基因座一直与中胚层形成和脊索分化有关。最近的研究表明，该基因编码一种假定的转录因子，在新生中胚层和分化中的脊索中特异性表达。已经从青蛙非洲爪蟾、斑马鱼短尾魮脂鲤和海鞘柄海鞘中克隆出了同源基因。T基因是阐明中胚层和胚胎模式形成的重要工具。
