转基因小鼠中的插入诱变
Insertional mutagenesis in transgenic mice.
作者信息
Rijkers T, Peetz A, Rüther U
机构信息
Institute for Molecular Biology, Medical School Hannover, Germany.
出版信息
Transgenic Res. 1994 Jul;3(4):203-15. doi: 10.1007/BF02336773.
PMID:7920737
Abstract
Increasing numbers of transgenic mouse lines have resulted in several dozens of mutants created by insertional mutagenesis. The advantages of different vector systems and the problems associated with the analysis of mutations and the cloning of the affected genes are discussed in this review.
摘要
越来越多的转基因小鼠品系已通过插入诱变产生了几十种突变体。本文综述讨论了不同载体系统的优点以及与突变分析和受影响基因克隆相关的问题。
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