Use of a single intrauterine insemination of defrosted cryopreserved sperm for therapeutic donor insemination.

OBJECTIVE

To evaluate the efficacy of a protocol employing defrosted cryopreserved sperm as a single well-timed intrauterine insemination.

DESIGN

A retrospective observational study.

SETTING

A university fertility service and a private fertility practice located in small metropolitan areas.

PARTICIPANTS

All 138 donor sperm recipients (348 cycles) treated on this protocol by the author during a 27 month period were evaluated. All 86 patients (200 cycles) treated using intracervical inseminations bracketing the time of ovulation during the same time period were also evaluated.

RESULTS

A single well-timed intrauterine insemination had an associated pregnancy rate of 13.8% per cycle. In contrast, intracervical inseminations bracketing the time of ovulation had an associated pregnancy rate of 5% per cycle (P < .005).

CONCLUSIONS

A single well-timed intrauterine insemination of defrosted cryopreserved sperm is more efficacious and less expensive than intracervical inseminations bracketing the time of ovulation.